The year 2025 saw Nancy Mace's political focus broaden from her work in the U.S. House toward a campaign for Governor of South Carolina in the 2026 cycle. She entered 2025 in her third term as the U.S. Representative for South Carolina's 1st congressional district, having been re-elected in 2024. During the year she announced her candidacy for governor, a race in which she would emerge as an early front-runner in internal polling.

A sourced timeline of 2025 milestones — committee work, notable votes, and the steps leading to the gubernatorial announcement — should be added as the record is compiled.